A2M - Advanced Therapies for Acute Injury and Osteoarthritis

Alpha 2 macroglobulin, or A2M is a concentrated protein injection therapy cultivated from your own plasma. A2M uses proven scientific techniques and natural healing methods to successfully treat in the early intervention of acute musculoskeletal injuries and osteoarthritis at its source by modulating cartilage-degrading enzymes to prevent cartilage breakdown. Once the signals for breakdown are inhibited, messengers and growth factors such as platelet derived growth factor (PDGF) and nerve growth factor (NGF) are activatedpromoting tissue growth and supporting the overall restoration of the affected joint.

What science tells us about A2M for Arthritis

Scientific evidence points to A2M as the key to stopping osteoarthritis at the molecular level. A2M is a Broad Spectrum Multi-Purpose Protease Inhibitor (powerful chemical in destroying proteins that cause arthritis) that captures and inactivates the three major chemicals that lead to joint breakdown and cartilage damage. Alpha-2-macroglobulin’s ability to generally inhibit proteases both in chronic and neuropathic pains and inflammatory joint problems provide relief of symptoms while promoting the body’s innate ability to heal.


Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L. Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis Rheumatol. 2014 Jul;66(7):1843-53. doi: 10.1002/art.38576. PMID: 24578232; PMCID: PMC4187342.

Montesano PX, Cuellar JM,(2017) Scuderi GJ. Intradiscal injection of an autologous alpha-2-macroglobulin concentrate alleviates back pain in FAC-positive patients. Ortho & Rheuma. ; 4(2): 555634.

Demirag B, Sarisozen B, Ozer O, Kaplan T, Ozturk C. Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases. J Bone Joint Surg Am. 2005 Nov;87(11):2401-10. doi: 10.2106/JBJS.D.01952. PMID: 16264114.

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I was dealing with some severe cervical spine issues, including a slipped disc and ongoing muscular pain, and I did both prolotherapy and PRP with Dr. Squires. She was thoughtful, thorough. I am now about 4 months pain free thanks to Dr. Squires expert care!

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